SEEM-Evolution | Jérémie Guedj | 27 juin 2014 ISEM

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Séminaire d’Ecologie et Evolution

 Vendredi 27 juin à 11:30 / Salle Louis Thaler (ISEM), UM2, bât 22, 2ème étage

Jérémie Guedj  

Modeling Hepatitis C Viral Kinetic in the Era of Direct Acting Antiviral Agents: review and perspectives

Chronic infection with Hepatitis C Virus (HCV) affects 130-200 million people worldwide, including nearly 8 million Europeans. In the last 10 years, active research on understanding mechanisms of HCV replication has resulted in the clinical implementation of direct acting antivirals (DAAs), holding the promise that a virtually universal cure might be achieved in the coming years.
Viral kinetic modeling aims to characterize the main mechanisms that govern the virologic response to treatment. These models, most often based on ordinary differential equations, have been initially developed in the field of HIV, providing estimates of key parameters, such as the treatment effectiveness in vivo, the half-life of productively infected cells or the daily rate of viral production.
In this talk I will review the mathematical and statistical developments that have been made in the recent years to apply these models to hepatitis C virus. I will show how these models have been used to guide efforts in clinical drug development. I will conclude on the future challenges on HCV viral kinetic modeling.


SEEM INVITE – Marie-Anne Félix – 6 juin à 11h Amphithéâtre du CNRS

Séminaire d’Ecologie et Evolution
(contact : Patrick Lemaire)
Vendredi 6 juin à 11:00
Amphithéâtre du CNRS / 1919 Route de Mende, Montpellier

Biological processes are generally studied in the laboratory under one environmental condition and in one reference genetic background. We try to widen this horizon to answer questions on the relationship between genetic and phenotypic evolution, by placing a paradigmatic model system in developmental biology, C. elegans vulval cell fate patterning, in its evolutionary context. We study properties of robustness, evolutionary variation and evolvability of this system.

In order to develop an evolutionary and ecological framework for C. elegans, we isolate and study natural populations of C. elegans and its relatives.Natural pathogens provide strong and changing selection pressures and are thus relevant to study the defense systems of C. elegans and their potentially rapid evolution. Several natural pathogens of C. elegans were isolated, including the first viruses that infect C. elegans or C. briggsae. A genome-wide association study of Orsay RNA virus load after infection of a worldwide set of C. elegans isolates indicates one major locus segregating in the species. We found that this major locus corresponds to a widespread deletion inactivating the homolog of vertebrate RIG-I viral sensors, thus allowing viral replication.