I am currently a second year PhD student in Medical Entomology and Parasitology at University of Abomey-Calavi (UAC-Benin) co-led by Institute of Evolutionary Sciences of Montpellier (ISEM-France) and Regional Institute of Public Health (IRSP/UAC-BENIN). I received a DPF/IRD doctoral training scholarship for the doctoral research between Benin and Montpellier on the theme: “Study of influence of duplications at ace-1 locus on insecticide resistance in Anopheles gambiae, a main malaria vector in West Africa”.
Insecticides are a major tool malaria control. In public health, pyrethroids are the only insecticides used for treating mosquito nets. Resistances to these insecticides were observed in the main malaria vectors in Africa, including Anopheles gambiae, and recent studies suggested that these resistances may contribute to the failure of vector control programs. Organophosphorus (OP) and carbamates (CX) insecticides are beginning to be considered and used as alternatives. The ace-1R allele confering cross-resistance to OP and CX has been identified in An. gambiae in West Africa and is being strengthened by the presence of a new allele duplicated (ace-1D) which seems to have a better fitness. Recognizing the importance of preserving the effectiveness of vector control, it is imperative to generate new knowledge on this duplicated allele (geographic distribution, evolutionary dynamics, and selective value) to assess its impact on vector control methods based on the use of OP and CX. This thesis project is part of the ANR “AlterNet” project is a collaboration IRD (MIVEGEC), the Research Institute of Health Science/Centre Muraz (Bobo Dioulasso, Burkina Faso) and IRSP-Ouidah.