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Mathieu Sicard

University professor Team Evolution, Vecteurs, Adaptation et Symbioses
Phone +33 (0)4 67 14 32 89
Localization bâtiment 22, étage 1
Mots clés Symbiosis Co-evolution Invertebrate immunity Parasitism Pathogens

My research focuses on the study of co-evolution in symbiotic interactions between eukaryotes and prokaryotes with a particular emphasis on the consequences of this process on partners’ life history traits (especially host immune system). I mainly conduct my experiments on two symbiotic models: (1) the intracellular symbionts Wolbachia which infect a wide range of arthropods (Mosquitoes, Terrestrial isopods etc.); (2) the extracellular symbionts Xenorhabdus and Photorhabdus which are both mutualistic for nematodes and pathogenic for insects.

Sicard, M., Brugirard, K., Lanois, A., Boemare, N., Bréhelin,  M. and Givaudan,  A. 2004. Stages of infection process during the tripartite interaction between Xenorhabdus nematophila, its nematode vector and insect hosts.
Applied and Environmental Microbiology, 70 (11) p6473-6480

 Sicard, M., Hering, S., Schulte, R., Gaudriault, S. and Schulenburg, H. 2007. The effect of Photorhabdus luminescens (Enterobacteriaceae) on the survival, development, reproduction and behaviour of Caenorhabditis elegans (Nematoda: Rhabditidae). Environmental Microbiology, 9 (1) p12-25

Braquart-Varnier, C., Lachat, M., Herbinière, J., Johnson, M., Caubet, Y., Bouchon D. and Sicard, M. 2008. Wolbachia mediate variation of host immunocompetence. PLoS ONE 3(9): e3286. doi:10.1371/journal.pone.0003286

Le Clec’h, W., Braquart-Varnier, C., Raimond, M., Ferdy, J-B, Bouchon, D. et Sicard, M. 2012. High virulence of Wolbachia after host switching: When autophagy hurts. PLoS Pathogens 8(8): e1002844. doi:10.1371/journal.ppat.1002844

Le Clec’h, W., Raimond, M., Guillot, S., Bouchon, D. and Sicard, M. 2013
Horizontal transfers of feminizing versus non feminizing Wolbachia strains: from harmless passengers to pathogens. Environmental Microbiology DOI: 10.1111/1462-2920.12172