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Pierre-Alexandre Gagnaire

CNRS research scientist Team Spéciation, Évolution et Adaptation en milieu marin
Localization Bât 24, 1er étage
Mots clés Local adaptation Phenotype Population genomics Demographic history Speciation

My research work focuses on the evolutionary processes driving local adaptation and speciation in natural populations. I am particularly interested in the population genetic mechanisms underlying adaptation to spatially heterogeneous habitats and the building of reproductive isolation among post glacial populations. Related interests concern the inference of demographic history, patterns of molecular evolution at the genomic level, and the genetic architecture of complex phenotypic traits. The main approach to these questions is through next-generation sequencing of natural populations samples and crossing experiments in the lab. These empirical approaches are combined with predictions from theoretical models in an integrative fashion. My study systems are marine species with high effective population sizes and migration rates that offer ideal population genetic parameters for studying adaptation and speciation.

1. GAGNAIRE, P.-A., S. A. PAVEY, E. NORMANDEAU and L. BERNATCHEZ, 2013. The genetic architecture of reproductive isolation during speciation-with-gene-flow in lake whitefish species pairs assessed by RAD-sequencing. Evolution 67: 2483–2497

2. GAGNAIRE, P. A., E. NORMANDEAU, S. A. PAVEY and L. BERNATCHEZ, 2013. Mapping phenotypic, expression and transmission ratio distortion QTL using RAD markers in the Lake Whitefish (Coregonus clupeaformis). Molecular Ecology 22: 3036–3048

3. GAGNAIRE, P.-A., E. NORMANDEAU and L. BERNATCHEZ, 2012. Comparative Genomics Reveals Adaptive Protein Evolution and a Possible Cytonuclear Incompatibility between European and American Eels. Molecular Biology and Evolution 29: 2909–2919

4. GAGNAIRE, P.-A., E. NORMANDEAU, C. CÔTÉ, M. M. HANSEN and L. BERNATCHEZ, 2012. The Genetic Consequences of Spatially Varying Selection in the Panmictic American Eel (Anguilla rostrata). Genetics 190: 725–736

5. GAGNAIRE, P.-A., Y. MINEGISHI, S. ZENBOUDJI, P. VALADE, J. AOYAMA and P. BERREBI, 2011. Within-population structure highlighted by differential introgression across semipermeable barriers to gene flow in Anguilla marmorata. Evolution 65: 3413–3427